Welcome to the Klein Lab!

The Klein Lab is a neuroimmunology research laboratory located at Washington University School of Medicine. We are interested in defining fundamental processes of the neuroimmune system – which is structurally and cellularly distinct from the peripheral immune system – that protect neurons from infection and inflammation. Our research particularly explores how innate immune responses of glial cells orchestrate all functions of the neuroimmune system including the regulation of pathogen entry and infection, recruitment of peripheral immune cells, and induces processes that promote repair during neuroinflammatory diseases.

The Center for Neuroimmunology & Neuroinfectious Diseases (CNND) brings together a multidisciplinary group of scientists, clinician-scientists and clinicians whose work is focused on the pathogenesis, diagnosis and treatment of neuroinflammatory and neuroinfectious diseases of the nervous system. Together we provide comprehensive, integrative care for adults and develop new treatments for a wide range of autoimmune and infectious illnesses of the central and peripheral nervous systems.